There is strong evidence demonstrating that nifedipine dissolved in ethanol selectively inhibits only L-type Ca2+ current. In addition, acute ethanol exposure reduces voltage-dependent calcium currents. In the present study, we investigated the antagonistic effect of fixed concentration of nifedipine dissolved in different concentration of ethanol on L-type Ca2+ current. In a Na+-K+ free solution, nifedipine dissolved in 60 and 120 mM ethanol decreased resting membrane potential of Ca2+ spikes and caused a significant reduction in amplitude, duration and an increase in threshold of Ca2+ spikes. Furthermore, Ca2+ current was inhibited by ethanol in a concentration-dependent manner, so that the reduction of L-type Ca2+ current by nifedipine/60 and 120 mM ethanol was statistically significant. Meanwhile, ethanol concentration-dependent response of Ca2+ currents was observed at its late component in more positive potentials. These results may be consistent with ethanol-dependent inhibition of L-type Ca2+ currents and ethanol-dependent enhancment of a Ca2+-activated potassium current
Baluchnejad Mojarad,T , Roghani,M and Janahmadi,M . (2003). Modification of Nifedipine Inhibitory Effect on Calcium Spike and L-Type Calcium Current by Ethanol in F1 Neuron of Helix aspersa. Iranian Biomedical Journal, 7(3), 99-105.
MLA
Baluchnejad Mojarad,T , , Roghani,M , and Janahmadi,M . "Modification of Nifedipine Inhibitory Effect on Calcium Spike and L-Type Calcium Current by Ethanol in F1 Neuron of Helix aspersa", Iranian Biomedical Journal, 7, 3, 2003, 99-105.
HARVARD
Baluchnejad Mojarad T, Roghani M, Janahmadi M. (2003). 'Modification of Nifedipine Inhibitory Effect on Calcium Spike and L-Type Calcium Current by Ethanol in F1 Neuron of Helix aspersa', Iranian Biomedical Journal, 7(3), pp. 99-105.
CHICAGO
T Baluchnejad Mojarad, M Roghani and M Janahmadi, "Modification of Nifedipine Inhibitory Effect on Calcium Spike and L-Type Calcium Current by Ethanol in F1 Neuron of Helix aspersa," Iranian Biomedical Journal, 7 3 (2003): 99-105,
VANCOUVER
Baluchnejad Mojarad T, Roghani M, Janahmadi M. Modification of Nifedipine Inhibitory Effect on Calcium Spike and L-Type Calcium Current by Ethanol in F1 Neuron of Helix aspersa. Iranian Biomedical Journal. 2003;7(3):99-105.
Iranian Biomedical Journal