The Role of High-Fructose Diet in Liver Function of Rodent Models: A Systematic Review of Molecular Analysis

Authors
Roya Mirzaei 1
Roya Khosrokhavar 2
Sepideh Arbabi Bidgoli 1
1 Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2 Food and Drug Laboratory Research Center, Food and Drug Administration, MOH&ME, Tehran, Iran
10.61186/ibj.27.6.326
Abstract
The present systematic review of animal studies on long-term fructose intake in rodents revealed a significant decrease in the activities of antioxidant enzymes due to a fructose-rich diet. The reduced activity of these enzymes led to an increase in oxidative stress, which can cause liver damage in rodents. Of eight studies analyzed, 5 (62.5%) and 1 (12.5%) used male and female rats, respectively, while 2 studies (25%) used female mice. Moreover, half of the studies used high-fructose corn syrup, but the other half employed fructose in the diet. Hence, it is essential to monitor dietary habits to ensure public health and nutrition research outcomes.
Keywords
animal model
Fructose
Liver
Liver function tests
Oxidative stress