Vaccine Candidates against Nontypeable Haemophilus influenzae: a Review

Authors
Ava Behrouzi 1
Farzam Vaziri 1
Fatemeh Rahimi-Jamnani 1
Parviz Afrough 1
Mohammad Rahbar 2
Fereshteh Satarian 1
Seyed Davar Siadat 1
1 Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
2 Department of Microbiology, Reference Health Laboratories Research Center, Ministry of Health and Medical Education, Tehran, Iran
10.18869/acadpub.ibj.21.2.69
Abstract
Nonencapsulated, nontypeable Hemophilus influenzae (NTHi) remains an important cause of acute otitis and respiratory diseases in children and adults. NTHi bacteria are one of the major causes of respiratory tract infections, including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in developing countries. The bacteria can also cause chronic diseases such as chronic bronchitis and chronic obstructive pulmonary disease in the lower respiratory tract of adults. Such bacteria express several outer membrane proteins, some of which have been studied as candidates for vaccine development. Due to the lack of effective vaccines as well as the spread and prevalence of NTHi worldwide, there is an urgent need to design and develop effective vaccine candidates against these strains.
Keywords
Vaccines
Chronic Obstructive Pulmonary Disease
Haemophilus influenzae