Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014

Authors
Mohammad Salehi 1
Seyyed Khalil Shokouhi Mostafavi 2
Abdolmajid Ghasemian 3
Mahmoud Gholami 4
Abdolrahim Kazemi-Vardanjani 5
Mohammad Karim Rahimi 2
1 Medical Diagnostic Laboratory of Neyshabour, Center of Medical, Pathological and Genetic Diagnostic Services, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran
2 Department of Microbiology, Islamic Azad University, Tehran Medical Science Branch, Tehran, Iran
3 Department of Microbiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran
4 Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran
5 Shahrekord University of Medical Sciences, Shahrek
10.18869/acadpub.ibj.21.1.57
Abstract
Background: Retroviruses of human T-lymphotropic viruses (HTLV-1 and HTLV-2) have been demonstrated to be endemic in the north-eastern region of Iran. This study aims to determine HTLV-1 and HTLV-2 prevalence among healthy individuals in Neyshabur City during 2010-2014. Methods: A total of 8054 blood samples were collected from healthy participants in Neyshabur, North-Eastern Iran. The blood samples were screened for the presence of specific antibodies against HTLV-1 and HTLV-2 by using ELISA according to the manufacturer’s instructions. Results: The overall seropositivity rate for HTLV-1 and HTLV-2 was found to be 6.55% (528 out of 8054) among participants. Conclusion: Both HTLV-1 and HTLV-2 were demonstrated to be at a high rate in healthy individuals. However, a smaller number of asymptomatic carriers were found in this study, as compared to those identified in previous investigations in the city.
Keywords
Human T-lymphotropic viruse
Seroepidemiology
Enzyme-Linked Immunosorbent Assay
Iran