Significant Changes in the Activity of L-Glutamic Acid Decarboxylase of Mouse Hypothalamus After Peripheral Injection of Cholecystokinin-8 and Caerulein
The activity of one of the metabolizing enzymes of - aminobutyric acid, (GABA), was determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (CCK-8) and caerulein (CLN). The activity of this rate-limiting enzyme, L-glutamic acid decarboxylase, (GAD), did not change thirty minutes after peripheral injections of either CCK-8 or CLN in doses of 50g/kg body weight. However, the activity of GAD started to increase 24 hours after injection and continued to increase by 15 to 17%, five days after injections. Based on the in vitro models, it has been shown that there are no direct interactions between CCK-8 and CLN and the enzyme GAD. These data probably support indirect but specific interactions between CCK-8, CLN and the enzyme GAD.
Yazdanparast,R and Qujeq,D . (1999). Significant Changes in the Activity of L-Glutamic Acid Decarboxylase of Mouse Hypothalamus After Peripheral Injection of Cholecystokinin-8 and Caerulein. Iranian Biomedical Journal, 3(1), 47-51.
MLA
Yazdanparast,R , and Qujeq,D . "Significant Changes in the Activity of L-Glutamic Acid Decarboxylase of Mouse Hypothalamus After Peripheral Injection of Cholecystokinin-8 and Caerulein", Iranian Biomedical Journal, 3, 1, 1999, 47-51.
HARVARD
Yazdanparast R, Qujeq D. (1999). 'Significant Changes in the Activity of L-Glutamic Acid Decarboxylase of Mouse Hypothalamus After Peripheral Injection of Cholecystokinin-8 and Caerulein', Iranian Biomedical Journal, 3(1), pp. 47-51.
CHICAGO
R Yazdanparast and D Qujeq, "Significant Changes in the Activity of L-Glutamic Acid Decarboxylase of Mouse Hypothalamus After Peripheral Injection of Cholecystokinin-8 and Caerulein," Iranian Biomedical Journal, 3 1 (1999): 47-51,
VANCOUVER
Yazdanparast R, Qujeq D. Significant Changes in the Activity of L-Glutamic Acid Decarboxylase of Mouse Hypothalamus After Peripheral Injection of Cholecystokinin-8 and Caerulein. Iranian Biomedical Journal. 1999;3(1):47-51.
Iranian Biomedical Journal