Continuous four hours EEG (electroencephalogram) recordings and its power spectrum analysis using fast fourier transform (FFT) in urethane anesthetized male Charles Foster rats were performed in two groups: open brain injury and p-CPA (para-Chlorophenylalanine) pretreated before brain injury, respectively, and compared with the EEG power spectrum of control rats. The EEG power spectrum analysis showed that there was a faster recovery in p-CPA pretreated group than the injury group of rats. The results showed that the p-CPA (a 5-HT inhibitor) prevents pathological changes following brain injury. Simultaneously, the inference can also be drawn that EEG power spectrum analysis is a useful technique for monitoring the brain injury and its recovery following pharmacological treatments
Sinha,R K and Ray,A K . (2003). Effect of p-CPA Pretreatment on EEG Power Spectra in Experimental Open Brain Injury in Rats. Iranian Biomedical Journal, 7(3), 119-126.
MLA
Sinha,R K , and Ray,A K . "Effect of p-CPA Pretreatment on EEG Power Spectra in Experimental Open Brain Injury in Rats", Iranian Biomedical Journal, 7, 3, 2003, 119-126.
HARVARD
Sinha R K, Ray A K. (2003). 'Effect of p-CPA Pretreatment on EEG Power Spectra in Experimental Open Brain Injury in Rats', Iranian Biomedical Journal, 7(3), pp. 119-126.
CHICAGO
R K Sinha and A K Ray, "Effect of p-CPA Pretreatment on EEG Power Spectra in Experimental Open Brain Injury in Rats," Iranian Biomedical Journal, 7 3 (2003): 119-126,
VANCOUVER
Sinha R K, Ray A K. Effect of p-CPA Pretreatment on EEG Power Spectra in Experimental Open Brain Injury in Rats. Iranian Biomedical Journal. 2003;7(3):119-126.
Iranian Biomedical Journal