A proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis B (HB) vaccine. Unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group of responder and non-responder neonates. Our results indicate significantly decreased production of HBsAg-induced IL-12 in non-responder subjects compared to responders (P<0.01). Since IL-12 is produced mainly by antigen presenting cells (APC) and is considered to be crucial for initiation and polarization of CD4+ T-cell function, therefore, our findings could be interpreted to imply APC dysfunction in non-responder vaccinees
Jafarzadeh,A , Kardar,G A , Khoshnoodi,J and Shokri,F . (2004). Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine. Iranian Biomedical Journal, 8(1), 41-45.
MLA
Jafarzadeh,A , , Kardar,G A , , Khoshnoodi,J , and Shokri,F . "Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine", Iranian Biomedical Journal, 8, 1, 2004, 41-45.
HARVARD
Jafarzadeh A, Kardar G A, Khoshnoodi J, Shokri F. (2004). 'Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine', Iranian Biomedical Journal, 8(1), pp. 41-45.
CHICAGO
A Jafarzadeh, G A Kardar, J Khoshnoodi and F Shokri, "Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine," Iranian Biomedical Journal, 8 1 (2004): 41-45,
VANCOUVER
Jafarzadeh A, Kardar G A, Khoshnoodi J, Shokri F. Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine. Iranian Biomedical Journal. 2004;8(1):41-45.
Iranian Biomedical Journal